Cheap Flights from Knoxville TN to San Diego International CA from $180

Compare Knoxville to San Diego International flight deals

Find the cheapest month or even day of the year to fly to San Diego International

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Flight deals from Knoxville to San Diego International

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to San Diego International? Find the lowest prices on one-way and round-trip tickets right here.

San Diego.$180 per passenger.Departing Thu, Apr 10, returning Thu, Apr 17.Round-trip flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departing from Knoxville on Thu, Apr 10, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departing from San Diego International on Thu, Apr 17, arriving in Knoxville.Price includes taxes and charges.From $180, select.

San Diego.$228 per passenger.Departing Sat, Sep 6, returning Sat, Sep 13.Round-trip flight with United.Outbound indirect flight with United, departing from Knoxville on Sat, Sep 6, arriving in San Diego International.Inbound indirect flight with United, departing from San Diego International on Sat, Sep 13, arriving in Knoxville.Price includes taxes and charges.From $228, select.

San Diego.$274 per passenger.Departing Sat, May 17, returning Tue, May 20.Round-trip flight with United.Outbound indirect flight with United, departing from Knoxville on Sat, May 17, arriving in San Diego International.Inbound indirect flight with United, departing from San Diego International on Tue, May 20, arriving in Knoxville.Price includes taxes and charges.From $274, select.

San Diego.$299 per passenger.Departing Wed, Jun 25, returning Sun, Jun 29.Round-trip flight with United.Outbound indirect flight with United, departing from Knoxville on Wed, Jun 25, arriving in San Diego International.Inbound indirect flight with United, departing from San Diego International on Sun, Jun 29, arriving in Knoxville.Price includes taxes and charges.From $299, select.

San Diego.$316 per passenger.Departing Mon, Jul 14, returning Tue, Jul 22.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Knoxville on Mon, Jul 14, arriving in San Diego International.Inbound indirect flight with Delta, departing from San Diego International on Tue, Jul 22, arriving in Knoxville.Price includes taxes and charges.From $316, select.

San Diego.$378 per passenger.Departing Fri, Mar 21, returning Tue, Mar 25.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Knoxville on Fri, Mar 21, arriving in San Diego International.Inbound indirect flight with Delta, departing from San Diego International on Tue, Mar 25, arriving in Knoxville.Price includes taxes and charges.From $378, select.

San Diego.$383 per passenger.Departing Sat, Sep 6, returning Fri, Oct 10.Round-trip flight with United.Outbound indirect flight with United, departing from Knoxville on Sat, Sep 6, arriving in San Diego International.Inbound indirect flight with United, departing from San Diego International on Fri, Oct 10, arriving in Knoxville.Price includes taxes and charges.From $383, select.

San Diego.$502 per passenger.Departing Sun, Oct 5, returning Sun, Oct 12.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Knoxville on Sun, Oct 5, arriving in San Diego International.Inbound indirect flight with Delta, departing from San Diego International on Sun, Oct 12, arriving in Knoxville.Price includes taxes and charges.From $502, select.

Find the cheapest month to fly from Knoxville to San Diego International

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to San Diego International flights are currently cheapest in April.

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Knoxville to San Diego International: Alternative routes

Compare routes from Knoxville to San Diego below. You may find an airport to fly into that's cheaper, faster, or easier than San Diego International.

Knoxville to San Diego: Flight information

The things to know before you go.

Cheapest flight found	$180
Cheapest month to fly	April

Finding cheap flights from Knoxville to San Diego International: Frequently asked questions

How much are round-trip flights from Knoxville to San Diego International?

The best price we found for a round-trip flight from Knoxville to San Diego International is $180. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Knoxville to San Diego International?

Currently, there are no airlines that fly direct from Knoxville to San Diego International. But we found flights with one or more stops from $180.

How many flights are there a week from Knoxville to San Diego International?

There are no flights flying from Knoxville to San Diego International, as of March 2025.

When is the cheapest time to fly from Knoxville to San Diego International?

The cheapest month to fly from Knoxville to San Diego International is usually March 2025.

Which upcoming date is cheapest to fly from Knoxville Airport to San Diego International Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to San Diego International Airport on Thursday, April 10, 2025.

Can I get a direct flight from Knoxville Airport to San Diego International Airport?

No airlines currently offer direct flights between Knoxville Airport and San Diego International Airport. Most routes have one or more stops.

How can I find the best flight deal to San Diego International?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Diego International but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to San Diego?

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to San Diego is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly with from Knoxville Airport to San Diego International?

Currently, Frontier Airlines offers the cheapest flight tickets to San Diego International.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to San Diego International Airport (SAN)

$96 is currently the lowest price for a one-way ticket from McGhee Tyson Airport to San Diego International Airport. Return flights start at $180. These prices can change depending on demand.
To find cheap tickets from TYS to SAN, book early. Airlines typically offer the most competitive fares when flights are first released.
Finding cheap tickets from McGhee Tyson Airport to San Diego International Airport is easy if you're flexible with your travel dates. Try using the 'Whole month' search function to see the lowest fares across every month and snap up a great deal.
Log into your online account or use the app to create a Price Alert. We'll notify you right away if there's a cheaper deal on this route. It's simple to do, and it'll save you the hassle of looking for cheap tickets from TYS to SAN every day.
Tailor your trip with filters. Pick your arrival and departure times, airlines and total journey duration. You can also sort results by 'Cheapest,' 'Best' or 'Fastest' flights from McGhee Tyson Airport to San Diego International Airport.

Handy information about McGhee Tyson Airport (TYS)

To get to McGhee Tyson Airport from central Knoxville, it'll take around 19 minutes if you're going by car. Of course, this depends on traffic conditions. It's approximately 23 kilometers from the airport to the city center.
Want an easy start to your trip? Stay near TYS. Whether you're on an early flight from McGhee Tyson Airport to San Diego International Airport or just don't like being rushed, these stays are perfect:

Arriving at San Diego International Airport (SAN)

The last thing you need is a lengthy journey to your hotel if you're landing late on a flight from McGhee Tyson Airport to San Diego International Airport. Stay at one of these accommodation options near SAN instead:

Getting from San Diego International Airport (SAN) to central San Diego

From San Diego International Airport, San Diego is approximately 5 kilometers away. It takes around 9 minutes to get to the center driving.
If you're using public transport, expect a journey of around 20 minutes.

When to fly to San Diego International Airport (SAN)

It's time to pick your dates for your flight from McGhee Tyson Airport to San Diego International Airport. July is the most popular month to visit San Diego. If you prefer a quieter vibe, go in May.
The warmest month in San Diego is August, with the temperature ranging between 17ºC and 28ºC. Lock in your flights from McGhee Tyson Airport to San Diego International Airport in this month if you enjoy this type of weather.
For cooler conditions, look for a cheap ticket from TYS to SAN in February. Average temperatures are between 7ºC and 23ºC then.

More about San Diego

If you're looking for somewhere to rest your head, you'll find the best places to stay in San Diego right here. Explore these hotels as soon as you've locked in your flight from TYS to SAN:
Every great vacation has to include some sightseeing. San Diego Zoo, USS Midway Museum and SeaWorld San Diego are must-visits when exploring San Diego.

Complete your San Diego trip with hotels and a car rental

Once you've secured your cheap ticket to San Diego International Airport, check out the lowest prices and exclusive rates for hotels. You can also compare a range of car rental companies in one place to get the best car rental price for your San Diego escape.